Small molecule inhibitors of lysyl oxidases synergize with 5-azacytidine to restore erythropoiesis in myeloid neoplasms
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ABSTRACT: In this study, we assessed the effects of lysyl oxidase (LOX/LOXL) inhibition on the composition of extracellular matrix (ECM) produced by in vitro expanded bone marrow derived mesenchymal stromal cells (MSCs) of n=3 patients with myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN).
INSTRUMENT(S): TripleTOF 6600
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Stromal Cell Of Bone Marrow, Blood
DISEASE(S): Myelodysplastic/myeloproliferative Neoplasm
SUBMITTER: Victor Costina
LAB HEAD: Evelyn Jaeger
PROVIDER: PXD031217 | Pride | 2023-02-17
REPOSITORIES: Pride
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