Small molecule inhibitors of lysyl oxidases synergize with 5-azacytidine to restore erythropoiesis in myeloid neoplasms

ABSTRACT: In this study, we assessed the effects of lysyl oxidase (LOX/LOXL) inhibition on the composition of extracellular matrix (ECM) produced by in vitro expanded bone marrow derived mesenchymal stromal cells (MSCs) of n=3 patients with myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN).

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stromal Cell Of Bone Marrow, Blood

DISEASE(S): Myelodysplastic/myeloproliferative Neoplasm

SUBMITTER: Victor Costina  

LAB HEAD: Evelyn Jaeger

PROVIDER: PXD031217 | Pride | 2023-02-17

REPOSITORIES: Pride