PLATELET PROTEOME REVEALS FEATURES OF CELL DEATH, ANTIVIRAL RESPONSE AND VIRAL REPLICATION IN COVID-19.

ABSTRACT: This article provides the first proteomic analysis of platelets from COVID-19 patients. Our dataset shows that platelets are reprogrammed during severe COVID-19 and respond with the activation of type I interferon and cell death pathways, indicating platelet participation in the antiviral response. Additionally, identification of proteins involved in translation, mainly in non-surviving, and complete sequencing of SARS-CoV-2 genome call attention to platelets as viral repositories and markers poor prognosis in COVID-19.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Platelet

SUBMITTER: Monique Ramos de Oliveira Garcia  

LAB HEAD: Monique Ramos Oliveira Trugilho

PROVIDER: PXD031251 | Pride | 2022-08-12

REPOSITORIES: Pride