Proteomic profiling of healthy and SLE isolated B-cells

ABSTRACT: B cells orchestrate the autoimmune responses in patients with systemic lupus erythematosus (SLE), but broad based B-cell directed therapies only show modest efficacy while attenuating humoral immune responses to vaccines and inducing acquired immunodeficiency. used proteomic and transcriptomic analyses of B cells from patients with SLE and healthy individuals and demonstrated a dominant DDR in SLE B cells.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, Blood

DISEASE(S): Systemic Lupus Erythematosus

SUBMITTER: Martina Samiotaki  

LAB HEAD: Dimitrios Boumpas

PROVIDER: PXD031389 | Pride | 2022-08-26

REPOSITORIES: Pride