Proteomics

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MYC-driven mouse HCC proteomics

ABSTRACT: To identify proteomic signatures associated with hepatocellular carcinoma driven by MYC overexpression, proteomics was performed on the LAP-tTA/tetO-MYC mouse conditional liver cancer model. Upon MYC activation, mice form liver cancer. Differential proteomics was performed in "MYC on" (MYC-HCC) mouse liver tumors versus mouse control normal liver tissue (where MYC was not overexpressed to drive tumorigenesis -- "MYC off").

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Liver

SUBMITTER: Delaney Sullivan  

LAB HEAD: Sharon Pitteri

PROVIDER: PXD031478 | Pride | 2022-10-12

REPOSITORIES: Pride

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Publications

MYC oncogene elicits tumorigenesis associated with embryonic, ribosomal biogenesis, and tissue-lineage dedifferentiation gene expression changes.

Sullivan Delaney K DK   Deutzmann Anja A   Yarbrough Josiah J   Krishnan Maya S MS   Gouw Arvin M AM   Bellovin David I DI   Adam Stacey J SJ   Liefwalker Daniel F DF   Dhanasekaran Renumathy R   Felsher Dean W DW  

Oncogene 20221007 45

MYC is a transcription factor frequently overexpressed in cancer. To determine how MYC drives the neoplastic phenotype, we performed transcriptomic analysis using a panel of MYC-driven autochthonous transgenic mouse models. We found that MYC elicited gene expression changes mostly in a tissue- and lineage-specific manner across B-cell lymphoma, T-cell acute lymphoblastic lymphoma, hepatocellular carcinoma, renal cell carcinoma, and lung adenocarcinoma. However, despite these gene expression chan  ...[more]

PMID: 36207533

Publication: 1/2

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