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Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses

ABSTRACT: The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome and phosphoproteome. We showed the ebb and flow of several host responses in the lung across viral infection. The signaling pathways and kinases regulating networks were alternated at different phases of infection. Our study not only revealed the dynamics of lung pathophysiology and their underlying molecular mechanisms during SARS-CoV-2 infection, but also highlighted some molecules and signaling pathways that might guide future investigations on COVID-19 therapies.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Mus Musculus (mouse)

SUBMITTER: Xiao Xiao Tang

LAB HEAD: Xiao Xiao Tang

PROVIDER: PXD031574 | Pride | 2022-04-01

REPOSITORIES: Pride

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Multi-omics evaluation of SARS-CoV-2 infected mouse lungs reveals dynamics of host responses.

Wang Zhao Ni ZN Yang Xiang Sheng XS Sun Jing J Zhao Jin Cun JC Zhong Nan Shan NS Tang Xiao Xiao XX

iScience 20220222 3

The outbreak of Coronavirus disease 2019 (COVID-19) throughout the world has caused millions of death, while the dynamics of host responses and the underlying regulation mechanisms during SARS-CoV-2 infection are not well depicted. Lung tissues from a mouse model sensitized to SARS-CoV-2 infection were serially collected at different time points for evaluation of transcriptome, proteome, and phosphoproteome. We showed the ebb and flow of several host responses in the lung across the viral infect ...[more]

PMID: 35224468

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