Proteomics

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Proteomic profiling identifies co-regulated expression of splicing factors as a characteristic feature of intravenous leiomyomatosis

ABSTRACT: In this work, we undertake a comparative mass spectrometry-based proteomic analysis of intravenous leiomyoma (IVLM) and other smooth muscle tumours (uterine leiomyoma (uLM), soft tissue leiomyoma (stLM) and benign metastatic keiomyoma (BML). By utilising sequential window acquisition of all theoretical fragment ion spectra mass spectrometry (SWATH-MS), we quantified >2,400 proteins from FFPE samples and demonstrate that at the protein level, IVLM is characterised by the unique co-regulated expression of splicing factors that comprise the spliceosome.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Smooth Muscle

DISEASE(S): Leiomyoma

SUBMITTER: Lukas Krasny  

LAB HEAD: Paul Huang

PROVIDER: PXD031637 | Pride | 2022-08-12

REPOSITORIES: Pride

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Proteomic Profiling Identifies Co-Regulated Expression of Splicing Factors as a Characteristic Feature of Intravenous Leiomyomatosis.

Krasny Lukas L   Wilding Chris P CP   Perkins Emma E   Arthur Amani A   Guljar Nafia N   Jenks Andrew D AD   Fisher Cyril C   Judson Ian I   Thway Khin K   Jones Robin L RL   Huang Paul H PH  

Cancers 20220613 12

Intravenous leiomyomatosis (IVLM) is a rare benign smooth muscle tumour that is characterised by intravenous growth in the uterine and pelvic veins. Previous DNA copy number and transcriptomic studies have shown that IVLM harbors unique genomic and transcriptomic alterations when compared to uterine leiomyoma (uLM), which may account for their distinct clinical behaviour. Here we undertake the first comparative proteomic analysis of IVLM and other smooth muscle tumours (comprising uLM, soft tiss  ...[more]

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