Ontology highlight
ABSTRACT:
INSTRUMENT(S): Bruker Daltonics solarix series
ORGANISM(S): Homo Sapiens (human)
SUBMITTER: Petr Man
LAB HEAD: Petr Man
PROVIDER: PXD031707 | Pride | 2022-06-09
REPOSITORIES: Pride
Science advances 20220518 20
Isoprenoids are synthesized by the prenyltransferase superfamily, which is subdivided according to the product stereoisomerism and length. In short- and medium-chain isoprenoids, product length correlates with active site volume. However, enzymes synthesizing long-chain products and rubber synthases fail to conform to this paradigm, because of an unexpectedly small active site. Here, we focused on the human <i>cis</i>-prenyltransferase complex (h<i>cis</i>-PT), residing at the endoplasmic reticu ...[more]