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Ursodeoxycholic acid promoted TGF-β degradation

ABSTRACT: MS analysis of proteins interacting with PKA and TGF-β1 in HEK293T cells. MS analysis of immunoprecipitated TGF-β1 in HEK293T cells with TGF-β1 overexpression.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Lung, Epithelial Cell

DISEASE(S): Colon Cancer

SUBMITTER: shaofang xie

LAB HEAD: Cai Zhijian

PROVIDER: PXD031801 | Pride | 2022-06-28

REPOSITORIES: Pride

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Dataset's files

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			Action	DRS
	MS201900090_2_T_V_P.msf	Msf
	MS201900090_2_T_V_P.raw	Raw
	MS201900090_4_PKA.msf	Msf
	MS201900090_4_PKA.raw	Raw
	MS201900102_Con1.msf	Msf

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Publications

Ursodeoxycholic acid reduces antitumor immunosuppression by inducing CHIP-mediated TGF-β degradation.

Shen Yingying Y Lu Chaojie C Song Zhengbo Z Qiao Chenxiao C Wang Jiaoli J Chen Jinbiao J Zhang Chengyan C Zeng Xianchang X Ma Zeyu Z Chen Tao T Li Xu X Lin Aifu A Guo Jufeng J Wang Jianli J Cai Zhijian Z

Nature communications 20220614 1

TGF-β is essential for inducing systemic tumor immunosuppression; thus, blocking TGF-β can greatly enhance antitumor immunity. However, there are still no effective TGF-β inhibitors in clinical use. Here, we show that the clinically approved compound ursodeoxycholic acid (UDCA), by degrading TGF-β, enhances antitumor immunity through restraining Treg cell differentiation and activation in tumor-bearing mice. Furthermore, UDCA synergizes with anti-PD-1 to enhance antitumor immunity and tumor-spec ...[more]

PMID: 35701426

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