Proteome-wide pulse labeling reveals amyloid-impaired protein degradation in Alzheimer’s disease

ABSTRACT: We here present a large-scale proteome-wide profiling of protein turnover in Alzheimer's disease mice model. We integrated in vivo pulse-SILAC labeling and TMT multiplexing with novel mass spectrometry to precisely measure protein half-lives.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Ka Yang  

LAB HEAD: Junmin Peng

PROVIDER: PXD031830 | Pride | 2024-10-28

REPOSITORIES: Pride