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T-cell-derived Hodgkin lymphoma has motility characteristics intermediate between Hodgkin and anaplastic large cell lymphoma

ABSTRACT: Global proteomics profiling of anaplastic large cell lymphoma cell lines DEL, SU-DHL-1 (ALK+), Mac-1, Mac-2A (ALK-) as well as Hodgkin lymphoma cell lines L-428, L-540, L-1236 and HDLM-2.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): B Cell, T Cell, Cell Culture

DISEASE(S): Anaplastic Large Cell Lymphoma,Hodgkin's Lymphoma

SUBMITTER: Sylvia Hartmann

LAB HEAD: Sylvia Hartmann

PROVIDER: PXD031907 | Pride | 2022-08-12

REPOSITORIES: Pride

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T-cell-derived Hodgkin lymphoma has motility characteristics intermediate between Hodgkin and anaplastic large cell lymphoma.

Bein Julia J Flinner Nadine N Häupl Björn B Mathur Aastha A Schneider Olga O Abu-Ayyad Marwa M Hansmann Martin-Leo ML Piel Matthieu M Oellerich Thomas T Hartmann Sylvia S

Journal of cellular and molecular medicine 20220519 12

Classic Hodgkin lymphoma (cHL) is usually characterized by a low tumour cell content, derived from crippled germinal centre B cells. Rare cases have been described in which the tumour cells show clonal T-cell receptor rearrangements. From a clinicopathological perspective, it is unclear if these cases should be classified as cHL or anaplastic large T-cell lymphoma (ALCL). Since we recently observed differences in the motility of ALCL and cHL tumour cells, here, we aimed to obtain a better unders ...[more]

PMID: 35586951

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