Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Epithelial Cell
SUBMITTER: Alex von kriegsheim
LAB HEAD: Alex von Kriegsheim
PROVIDER: PXD031920 | Pride | 2023-05-10
REPOSITORIES: Pride
Hall Emma A EA Kumar Dhivya D Prosser Suzanna L SL Yeyati Patricia L PL Herranz-Pérez Vicente V García-Verdugo Jose Manuel JM Rose Lorraine L McKie Lisa L Dodd Daniel O DO Tennant Peter A PA Megaw Roly R Murphy Laura C LC Ferreira Marisa F MF Grimes Graeme G Williams Lucy L Quidwai Tooba T Pelletier Laurence L Reiter Jeremy F JF Mill Pleasantine P
eLife 20230215
Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by Pericentriolar material 1 (PCM1). To study the requirement for centriolar satellites, we generated mice lacking PCM1, a crucial component of satellites. <i>Pcm1<sup>-/-</sup></i> mice display partially penetrant perinatal lethality with survivors exhibiting hydrocephalus, oligospermia, and cerebellar hypoplasia, and variably expressive phenotypes such as hydronephrosis. As many of these phenotypes have ...[more]