Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Jifeng Wang
LAB HEAD: Wang Lei
PROVIDER: PXD032035 | Pride | 2022-08-12
REPOSITORIES: Pride
Liu Ping P Wang Xi X Sun Yiwei Y Zhao Hongyu H Cheng Fang F Wang Jifeng J Yang Fuquan F Hu Junjie J Zhang Hong H Wang Chih-Chen CC Wang Lei L
Redox biology 20220628
The replication machinery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely associated with the endoplasmic reticulum (ER) in host cells. Activation of the unfolded protein response (UPR) is a strategy hijacked by coronavirus to facilitate its replication and suppress host innate immunity. Here, we have found that SARS-CoV-2 ORF8 protein accumulates in the ER and escapes the degradation system by forming mixed disulfide complexes with ER oxidoreductases. ORF8 induces ...[more]