Cancer-derived branched-chain ketoacids modulate macrophage polarization and metabolic reprogramming

ABSTRACT: This study aims to uncover the effects of cancer-derived branched-chain ketoacids on macrophage polarization and the underlying mechanism. We uncovered the global responses of branched-chain ketoacids-stimulated macrophages by proteomics analysis. Functional enrihment analysis indicated that these ketoacids significantly altered macrophage metabolism, apoptosis and phagocytosis.

INSTRUMENT(S):

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Bone Marrow, Macrophage

SUBMITTER: Zhengnan Cai  

LAB HEAD: Wolfram Weckwerth

PROVIDER: PXD032100 | Pride | 2022-10-04

REPOSITORIES: Pride