Dataset Information

Tissue Catabolism and Donor-Specific Dexamethasone Response in a Human Osteochondral Model of Post-Traumatic Osteoarthritis

ABSTRACT: We present an ex vivo human osteochondral model of PTOA to investigate disease effects on catabolism and cellular homeostasis in a multi-tissue system and discover biomarkers for disease progression and drug efficacy.

INSTRUMENT(S): Q Exactive HF-X

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Ankle Joint, Articular Cartilage, Bone

DISEASE(S): Osteoarthritis

SUBMITTER: Patrik Onnerfjord

LAB HEAD: Patrik Önnerfjord

PROVIDER: PXD032213 | Pride | 2022-08-12

REPOSITORIES: Pride

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			Action	DRS
	210909_DDA_HDP6_OCM_D1_2c.raw	Raw
	210909_DDA_HDP6_OCM_D2_29b.raw	Raw
	210909_DDA_HDP6_OCM_D3_30b.raw	Raw
	210909_DDA_HDP6_OCM_IC1_31b.raw	Raw
	210909_DDA_HDP6_OCM_IC2_32b.raw	Raw

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Publications

Tissue catabolism and donor-specific dexamethasone response in a human osteochondral model of post-traumatic osteoarthritis.

Black Rebecca Mae RM Flaman Lisa L LL Lindblom Karin K Chubinskaya Susan S Grodzinsky Alan J AJ Önnerfjord Patrik P

Arthritis research & therapy 20220610 1

<h4>Background</h4>Post-traumatic osteoarthritis (PTOA) does not currently have clinical prognostic biomarkers or disease-modifying drugs, though promising candidates such as dexamethasone (Dex) exist. Many challenges in studying and treating this disease stem from tissue interactions that complicate understanding of drug effects. We present an ex vivo human osteochondral model of PTOA to investigate disease effects on cartilage and bone homeostasis and discover biomarkers for disease progressio ...[more]

PMID: 35689293

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