Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Hepatocyte, Liver
DISEASE(S): Non-alcoholic Fatty Liver Disease,Fatty Liver Disease
SUBMITTER: Birgit Knebel
LAB HEAD: Birgit Knebel
PROVIDER: PXD032214 | Pride | 2022-08-02
REPOSITORIES: Pride
Fahlbusch Pia P Nikolic Aleksandra A Hartwig Sonja S Jacob Sylvia S Kettel Ulrike U Köllmer Cornelia C Al-Hasani Hadi H Lehr Stefan S Müller-Wieland Dirk D Knebel Birgit B Kotzka Jörg J
International journal of molecular sciences 20220620 12
Alterations in mitochondrial function are an important control variable in the progression of metabolic dysfunction-associated fatty liver disease (MAFLD), while also noted by increased de novo lipogenesis (DNL) and hepatic insulin resistance. We hypothesized that the organization and function of a mitochondrial electron transport chain (ETC) in this pathologic condition is a consequence of shifted substrate availability. We addressed this question using a transgenic mouse model with increased h ...[more]