Dataset Information

MS-based proteomic characterization of Toxoplasma gondii BCC7 interactome

ABSTRACT: Toxoplasma gondii is an obligate intracellular protozoan parasite of a wide range of homeotherm animals worldwide. T. gondii belongs to the ancient phylum of Apicomplexa and shares with the other companion groups from the Alveolata infrakingdom, a featuring trilamellar pellicle outlining the cell while a permanent apico-basal polarity also characterizes the T. gondii zoites. In addition to the plasma membrane bilayer, the pellicle also encompasses the underneath inner membrane complex (IMC) itself derived from flattened and fused vesicles identified as alveoli and made of a IMC and IMC-like protein’s repertoire, yet to complete. We identified a 500 kDa protein encoded by TGGT1_311230, the basal complex component BCC7, exhibiting a posterior localization. To gain insight about the role of BCC7 in T. gondii, we characterized its interactome.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human) Toxoplasma Gondii Rh

SUBMITTER: Yohann Couté

LAB HEAD: Yohann Couté

PROVIDER: PXD032362 | Pride | 2022-07-25

REPOSITORIES: Pride

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Publications

The BCC7 Protein Contributes to the <i>Toxoplasma</i> Basal Pole by Interfacing between the MyoC Motor and the IMC Membrane Network.

Vigetti Luis L Labouré Tatiana T Roumégous Chloé C Cannella Dominique D Touquet Bastien B Mayer Claudine C Couté Yohann Y Frénal Karine K Tardieux Isabelle I Renesto Patricia P

International journal of molecular sciences 20220526 11

<i>T. gondii</i> is a eukaryotic parasite that has evolved a stage called tachyzoite which multiplies in host cells by producing two daughter cells internally. These nascent tachyzoites bud off their mother and repeat the division process until the expanding progenies escape to settle and multiply in other host cells. Over these intra- and extra-cellular phases, the tachyzoite maintains an essential apicobasal polarity that emerges through a unique bidirectional budding process of the elongating ...[more]

PMID: 35682673

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Dataset Information

MS-based proteomic characterization of Toxoplasma gondii BCC7 interactome

Publications

The BCC7 Protein Contributes to the <i>Toxoplasma</i> Basal Pole by Interfacing between the MyoC Motor and the IMC Membrane Network.

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