Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
SUBMITTER: Cyriel Olie
LAB HEAD: Benedikt M. Kessler
PROVIDER: PXD032406 | Pride | 2023-05-10
REPOSITORIES: Pride
Olie Cyriel Sebastiaan CS Pinto-Fernández Adán A Damianou Andreas A Vendrell Iolanda I Mei Hailiang H den Hamer Bianca B van der Wal Erik E de Greef Jessica C JC Raz Vered V Kessler Benedikt M BM
Cell death & disease 20230331 3
The ubiquitin proteasomal system is a critical regulator of muscle physiology, and impaired UPS is key in many muscle pathologies. Yet, little is known about the function of deubiquitinating enzymes (DUBs) in the muscle cell context. We performed a genetic screen to identify DUBs as potential regulators of muscle cell differentiation. Surprisingly, we observed that the depletion of ubiquitin-specific protease 18 (USP18) affected the differentiation of muscle cells. USP18 depletion first stimulat ...[more]