Proteomics

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Proteomics and Metabolomics unveils Codonopsis Radix ameliorates Gastric Precancerous Lesions via regulating energy metabolism

ABSTRACT: Modern pharmacology has proved that Codonopsis Radix and its active ingredients can treat stomach diseases by ameliorating gastrointestinal motility and regulating oxidase levels. However, the detailed molecular mechanism is still unclear. In this study, we systematically evaluated the pharmacodynamic effects of Codonopsis Radix in Gastric Precancerous Lesions animal models. Considering the combination of proteomics and metabolomics, we found that CR could significantly reversed the biological pathways related to energy metabolism which were disturbed by GPL model. Furthermore, the results of serum pharmacology indicated that the Codonopsis Radix contained serum could ameliorate gastritis injury, and selectively inhibit the proliferation of gastric cancer cells rather than normal cells, which was closely related to ATP production in above cells.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Rattus Norvegicus (rat)

TISSUE(S): Stomach

DISEASE(S): Stomach Disease

SUBMITTER: 茹芸 马  

LAB HEAD: Jianye Dai

PROVIDER: PXD032714 | Pride | 2022-10-15

REPOSITORIES: Pride

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Proteomics and Metabolomics Unveil <i>Codonopsis pilosula</i> (Franch.) Nannf. Ameliorates Gastric Precancerous Lesions <i>via</i> Regulating Energy Metabolism.

He Rupu R   Ma Ruyun R   Jin Zheng Z   Zhu Yanning Y   Yang Fude F   Hu Fangdi F   Dai Jianye J  

Frontiers in pharmacology 20220719

<b>Objective:</b> This study aimed to systematically evaluate the efficacy of <i>Codonopsis pilosula</i> (Franch.) Nannf. (<i>Codonopsis Radix</i>, CR) and reveal the mechanism of its effects on suppressing Gastric Precancerous Lesions. <b>Methods:</b> First, we established the GPL rat model which was induced by N-methyl-N'-nitro-N-nitrosoguanidine, a disordered diet, and 40% ethanol. The CR's anti-Gastric Precancerous Lesions effect was comprehensively evaluated by body weight, pathological sec  ...[more]

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