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Human Synthesis and preparation of histone3 modification peptides

ABSTRACT: Synthesis and preparation of histone3 modification peptides

INSTRUMENT(S): 4800 Proteomics Analyzer

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Breast Cancer

SUBMITTER: Josh Haipeng Lei

LAB HEAD: Hong Yan Sun

PROVIDER: PXD032850 | Pride | 2022-05-20

REPOSITORIES: Pride

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FGFR2-BRD4 Axis Regulates Transcriptional Networks of Histone 3 Modification and Synergy Between Its Inhibitors and PD-1/PD-L1 in a TNBC Mouse Model.

Lei Josh Haipeng JH Zhang Lei L Wang Zhenyi Z Peltier Raoul R Xie Yusheng Y Chen Ganchao G Lin Shiqi S Miao Kai K Deng Chu-Xia CX Sun Hongyan H

Frontiers in immunology 20220425

Epigenetic reprogramming is an independent mode of gene expression that often involves changes in the transcription and chromatin structure due to tumor initiation and development. In this study, we developed a specifically modified peptide array and searched for a recognized epigenetic reader. Our results demonstrated that BRD4 is not only an acetylation reader but of propionylation as well. We also studied the quantitative binding affinities between modified peptides and epigenetic regulators ...[more]

PMID: 35547739

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