Proteomics

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Sweat proteomic of cystic fibrosis patients

ABSTRACT: Sweat plays a crucial role in thermo-regulation and skin health and potentially antimicrobial defense. Its composition is highly dynamic and its homeostasis involves a fine tuning of metabolic pathways. In-depth profiling of sweat protein composition will increase our understanding of skin disorders. Cystic Fibrosis (CF) is associated with high NaCl sweat concentration due to the absence of the CFTR protein. Patients with CF (pwCF) often display aquagenic palmoplantar keratodermia, a rare skin disorder characterized by skin wrinkling with oedema and whitish papules on the palms and/or soles, the pathophysiology of which is unknown. We report an in-depth analysis of the human sweat proteome of pwCF patients in comparison with that of healthy subjects (S).

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Sweat

DISEASE(S): Cystic Fibrosis

SUBMITTER: Chiara guerrera  

LAB HEAD: Chiara Guerrera

PROVIDER: PXD032894 | Pride | 2023-03-11

REPOSITORIES: Pride

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Publications

Proteomic profiling of sweat in patients with cystic fibrosis provides new insights into epidermal homoeostasis.

Cornet Matthieu M   Nguyen-Khoa Thao T   Kelly-Aubert Mairead M   Jung Vincent V   Chedevergne Frédérique F   Le Bourgeois Muriel M   Aoust Laura L   Roger Kévin K   Guerrera Chiara Ida CI   Sermet-Gaudelus Isabelle I  

Skin health and disease 20221125 1

<h4>Background</h4>A high proportion of patients with Cystic Fibrosis (CF) also present the rare skin disease aquagenic palmoplantar keratoderma. A possible link between this condition and absence of a functional CF Transmembrane conductance Regulator protein in the sweat acinus and collecting duct remains unknown.<h4>Methods</h4>In-depth characterization of sweat proteome profiles was performed in 25 CF patients compared to 12 healthy controls. A 20 μL sweat sample was collected after pilocarpi  ...[more]

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