Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Exploris 480
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Colon
DISEASE(S): Colon Cancer
SUBMITTER: Malwina Michalak
LAB HEAD: Juergen Kopitz
PROVIDER: PXD032902 | Pride | 2022-08-12
REPOSITORIES: Pride
Michalak Malwina M Golde Viola V Helm Dominik D Kaltner Herbert H Gebert Johannes J Kopitz Jürgen J
International journal of molecular sciences 20220608 12
Galectin-4 (Gal4) has been suggested to function as a tumor suppressor in colorectal cancer (CRC). In order to systematically explore its function in CRC, we established a CRC cell line where Gal4 expression can be regulated via the doxycycline (dox)-inducible expression of a single copy wildtype <i>LGALS4</i> transgene generated by recombinase-mediated cassette exchange (RMCE). Using this model and applying in-depth proteomic and phosphoproteomic analyses, we systematically screened for intrace ...[more]