Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Prostate Cancer
SUBMITTER: Sergio Lilla
LAB HEAD: Sara Rossana Zanivan
PROVIDER: PXD032911 | Pride | 2023-03-11
REPOSITORIES: Pride
Román-Fernández Alvaro A Mansour Mohammed A MA Kugeratski Fernanda G FG Anand Jayanthi J Sandilands Emma E Galbraith Laura L Rakovic Kai K Freckmann Eva C EC Cumming Erin M EM Park Ji J Nikolatou Konstantina K Lilla Sergio S Shaw Robin R Strachan David D Mason Susan S Patel Rachana R McGarry Lynn L Katoch Archana A Campbell Kirsteen J KJ Nixon Colin C Miller Crispin J CJ Leung Hing Y HY Le Quesne John J Norman James C JC Zanivan Sara S Blyth Karen K Bryant David M DM
Science advances 20230203 5
The glycocalyx component and sialomucin podocalyxin (PODXL) is required for normal tissue development by promoting apical membranes to form between cells, triggering lumen formation. Elevated PODXL expression is also associated with metastasis and poor clinical outcome in multiple tumor types. How PODXL presents this duality in effect remains unknown. We identify an unexpected function of PODXL as a decoy receptor for galectin-3 (GAL3), whereby the PODXL-GAL3 interaction releases GAL3 repression ...[more]