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Differential RNA aptamer affinity profiling on plasma as a potential diagnostic tool for bladder cancer

ABSTRACT: APTASHAPE is a new method for characterising the composition of complex biofluids Biomarker discovery is performed using blood from bladder cancer patients APTASHAPE can distinguish blood samples from patients with different stages of bladder cancer

INSTRUMENT(S): Orbitrap Fusion

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Plasma

DISEASE(S): Urinary Bladder Cancer

SUBMITTER: Søren Fjelstrup

LAB HEAD: Jørgen Kjems

PROVIDER: PXD032972 | Pride | 2022-10-14

REPOSITORIES: Pride

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Differential RNA aptamer affinity profiling on plasma as a potential diagnostic tool for bladder cancer.

Fjelstrup Søren S Dupont Daniel M DM Bus Claus C Enghild Jan J JJ Jensen Jørgen B JB Birkenkamp-Demtröder Karin K Dyrskjøt Lars L Kjems Jørgen J

NAR cancer 20220822 3

The molecular composition of blood is a signature of human health, reflected in the thousands of blood biomarkers known for human diseases. However, establishing robust disease markers is challenging due to the diversity of individual samples. New sequencing methods have simplified biomarker discovery for circulating DNA and RNA while protein profiling is still laborious and costly. To harness the power of high-throughput sequencing to profile the protein content of a biological sample, we devel ...[more]

PMID: 36004048

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