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Proteomic Analysis of Umbilical Cord and Adult Mesenchymal Stem Cells

ABSTRACT: Shotgun proteomic analysis was performed on lysates from umbilical cord and adjult mesenchymal stem cells

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Stem Cell

SUBMITTER: Sharon Pitteri

LAB HEAD: Sharon Pitteri

PROVIDER: PXD032994 | Pride | 2022-12-19

REPOSITORIES: Pride

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Integrated transcriptome-proteome analyses of human stem cells reveal source-dependent differences in their regenerative signature.

Ganguly Abantika A Swaminathan Ganesh G Garcia-Marques Fernando F Regmi Shobha S Yarani Reza R Primavera Rosita R Chetty Shashank S Bermudez Abel A Pitteri Sharon J SJ Thakor Avnesh S AS

Stem cell reports 20221208 1

Mesenchymal stem cells (MSCs) are gaining increasing prominence as an effective regenerative cellular therapy. However, ensuring consistent and reliable effects across clinical populations has proved to be challenging. In part, this can be attributed to heterogeneity in the intrinsic molecular and regenerative signature of MSCs, which is dependent on their source of origin. The present work uses integrated omics-based profiling, at different functional levels, to compare the anti-inflammatory, i ...[more]

PMID: 36493779

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