Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Saccharomyces Cerevisiae (baker's Yeast)
SUBMITTER: Jasjot Singh
LAB HEAD: Dominic Winter
PROVIDER: PXD033024 | Pride | 2023-01-11
REPOSITORIES: Pride
Song Jiyao J Steidle Liesa L Steymans Isabelle I Singh Jasjot J Sanner Anne A Böttinger Lena L Winter Dominic D Becker Thomas T
Nature communications 20230103 1
The mitochondrial F<sub>1</sub>F<sub>O</sub>-ATP synthase produces the bulk of cellular ATP. The soluble F<sub>1</sub> domain contains the catalytic head that is linked via the central stalk and the peripheral stalk to the membrane embedded rotor of the F<sub>O</sub> domain. The assembly of the F<sub>1</sub> domain and its linkage to the peripheral stalk is poorly understood. Here we show a dual function of the mitochondrial Hsp70 (mtHsp70) in the formation of the ATP synthase. First, it coopera ...[more]