Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Caro_0000000, Cell Culture
DISEASE(S): Kidney Cancer
SUBMITTER: Gao Song
LAB HEAD: Gao Song
PROVIDER: PXD033099 | Pride | 2023-10-24
REPOSITORIES: Pride
Luo Li L Wei Denghui D Pan Yihui Y Wang Qiu-Xia QX Feng Jian-Xiong JX Yu Bing B Kang Tiebang T Luo Junhang J Yang Jiefeng J Gao Song S
Cancer communications (London, England) 20230628 7
<h4>Background</h4>Clear cell renal cell carcinoma (ccRCC) is the most lethal renal cancer. An overwhelming increase of patients experience tumor progression and unfavorable prognosis. However, the molecular events underlying ccRCC tumorigenesis and metastasis remain unclear. Therefore, uncovering the underlying mechanisms will pave the way for developing novel therapeutic targets for ccRCC. In this study, we sought to investigate the role of mitofusin-2 (MFN2) in supressing ccRCC tumorigenesis ...[more]