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Putative tear fluid biomarkers of diabetic retinopathy

ABSTRACT: Identification of tear fluid biomarkers may offer a non-invasive strategy for detecting diabetic patients with increased risk of developing diabetic retinopathy (DR) or increased disease progression, thus helping both improving diagnostic accuracy and understanding the pathophysiology of the disease. The goal of this study was to characterize the proteomic profile of human tear fluid and examine changes in proteins expression in different stages of diabetic retinopathy.

INSTRUMENT(S): Q Exactive HF

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Tear

DISEASE(S): Retinopathy,Diabetes

SUBMITTER: Delphi Van Haver

LAB HEAD: Rosa Fernandes

PROVIDER: PXD033101 | Pride | 2022-05-31

REPOSITORIES: Pride

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Putative Biomarkers in Tears for Diabetic Retinopathy Diagnosis.

Amorim Madania M Martins Beatriz B Caramelo Francisco F Gonçalves Conceição C Trindade Grimalde G Simão Jorge J Barreto Patrícia P Marques Inês I Leal Ermelindo Carreira EC Carvalho Eugénia E Reis Flávio F Ribeiro-Rodrigues Teresa T Girão Henrique H Rodrigues-Santos Paulo P Farinha Cláudia C Ambrósio António Francisco AF Silva Rufino R Fernandes Rosa R

Frontiers in medicine 20220525

<h4>Purpose</h4>Tear fluid biomarkers may offer a non-invasive strategy for detecting diabetic patients with increased risk of developing diabetic retinopathy (DR) or increased disease progression, thus helping both improving diagnostic accuracy and understanding the pathophysiology of the disease. Here, we assessed the tear fluid of nondiabetic individuals, diabetic patients with no DR, and diabetic patients with nonproliferative DR (NPDR) or with proliferative DR (PDR) to find putative biomark ...[more]

PMID: 35692536

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