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Multi-omics approach to characterize sex-specific metabolic alterations in triple-transgenic Alzheimer's mouse brain

ABSTRACT: We aimed to characterise alterations in metabolic pathways and proteome composition in a mouse model of Alzheimer disease (AD). We specifically aimed to evaluate how these differences may be sex-specific by integrative multi-omics analysis (metabolites, lipids, proteins).

INSTRUMENT(S): timsTOF Pro

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Brain

DISEASE(S): Alzheimer's Disease

SUBMITTER: Manfredo Quadroni

LAB HEAD: Julijana Ivanisevic

PROVIDER: PXD033164 | Pride | 2023-03-11

REPOSITORIES: Pride

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Molecular insights into sex-specific metabolic alterations in Alzheimer's mouse brain using multi-omics approach.

Strefeler Abigail A Jan Maxime M Quadroni Manfredo M Teav Tony T Rosenberg Nadia N Chatton Jean-Yves JY Guex Nicolas N Gallart-Ayala Hector H Ivanisevic Julijana J

Alzheimer's research & therapy 20230109 1

<h4>Background</h4>Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized by altered cellular metabolism in the brain. Several of these alterations have been found to be exacerbated in females, known to be disproportionately affected by AD. We aimed to unravel metabolic alterations in AD at the metabolic pathway level and evaluate whether they are sex-specific through integrative metabolomic, lipidomic, and proteomic analysis of mouse brain tissue.<h4>Methods< ...[more]

PMID: 36624525

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