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Proteomic analysis of pigmented and amelanotic melanoma cells

ABSTRACT: Mass spectrometry-based proteomics comparison between amelanotic and pigmented melanoma cells for new biomarkers discovery.

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Homo Sapiens (human)

DISEASE(S): Skin Amelanotic Melanoma,Skin Melanoma

SUBMITTER: Cristian Munteanu

LAB HEAD: Ștefana M. Petrescu

PROVIDER: PXD033192 | Pride | 2023-02-14

REPOSITORIES: Pride

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New panel of biomarkers to discriminate between amelanotic and melanotic metastatic melanoma.

Militaru Ioana V IV Rus Alina Adriana AA Munteanu Cristian V A CVA Manica Georgiana G Petrescu Stefana M SM

Frontiers in oncology 20230126

Melanoma is a form of skin cancer that can rapidly invade distant organs. A distinctive feature of melanomas is their pigmentation status, as melanin is present in most skin melanomas, whilst many metastatic tumors could become amelanotic. Besides the obvious malfunction of the key genes of the melanin pathway, the amelanotic tumors could bear a characteristic molecular signature accounting for their aggressivity. Using mass spectrometry-based proteomics we report here a distinctive panel of bio ...[more]

PMID: 36776379

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