N-linked glycan analysis of native SARS-CoV-2 Delta variant Spike

ABSTRACT: The SARS-CoV-2 Delta variant is more contagious than WT and causes severe symptoms.To understand the elevated fusogenicity of Delta, we used LC-MS/MS to characterize the site specific N-linked glycan of spike protein in SARS-CoV-2 Delta variant virions.The glycan analysis revealed increased oligomannose-type glycosylation of native Delta spike over that of the Wuhan-Hu-1 spike.

INSTRUMENT(S):

ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2

TISSUE(S): Cell Culture

SUBMITTER: Yutong Song  

LAB HEAD: Sai Li

PROVIDER: PXD033342 | Pride | 2023-05-10

REPOSITORIES: Pride