Dataset Information
Label-free whole cell proteomics for oncogene cell lines
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive Plus
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Pancreatic Ductal Cell, B Cell, Osteoblast, Breast, Cell Culture, Prostate Epithelium
DISEASE(S): Osteosarcoma,Prostate Cancer,Burkitt Lymphoma,Pancreatic Cancer
SUBMITTER: 
Paige Solomon
LAB HEAD: Jim Wells
PROVIDER: PXD033373 | Pride | 2022-08-11
REPOSITORIES: Pride
Publications
Discovery Proteomics Analysis Determines That Driver Oncogenes Suppress Antiviral Defense Pathways Through Reduction in Interferon-β Autocrine Stimulation.
Molecular & cellular proteomics : MCP 20220518 7
Since the discovery of oncogenes, there has been tremendous interest to understand their mechanistic basis and to develop broadly actionable therapeutics. Some of the most frequently activated oncogenes driving diverse cancers are c-MYC, EGFR, HER2, AKT, KRAS, BRAF, and MEK. Using a reductionist approach, we explored how cellular proteomes are remodeled in isogenic cell lines engineered with or without these driver oncogenes. The most striking discovery for all oncogenic models was the systemati ...[more]
