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Proteins of outer membrane vesicles of Bordetella pertussis

ABSTRACT: proteome analysis OMV extracted from B. pertussis Tohama I wildtype

INSTRUMENT(S): Q Exactive

ORGANISM(S): Bordetella Pertussis (strain Tohama I / Atcc Baa-589 / Nctc 13251)

SUBMITTER: Kristin Surmann

LAB HEAD: Uwe Völker

PROVIDER: PXD033489 | Pride | 2023-05-03

REPOSITORIES: Pride

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Bordetella pertussis outer membrane vesicles as virulence factor vehicles that influence bacterial interaction with macrophages.

Blancá Bruno B Alvarez Hayes Jimena J Surmann Kristin K Hugo Valdez V Hentschker Christian C Lamberti Yanina Y Völker Uwe U Rodriguez María Eugenia ME

Pathogens and disease 20220801 1

Gram-negative pathogenic bacteria constitutively shed outer membrane vesicles (OMVs) which play a significant role in the host-pathogen interaction, eventually determining the outcome of the infection. We previously found that Bordetella pertussis, the etiological agent of whooping cough, survives the innate interaction with human macrophages remaining alive inside these immune cells. Adenylate cyclase (CyaA), one of the main toxins of this pathogen, was found involved in the modulation of the m ...[more]

PMID: 35927587

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