Ontology highlight
ABSTRACT:
INSTRUMENT(S): Bruker Daltonics timsTOF series
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Smooth Muscle Cell Of The Coronary Artery
SUBMITTER: Per Hägglund
LAB HEAD: Per Hägglund
PROVIDER: PXD033732 | Pride | 2023-02-01
REPOSITORIES: Pride
He Jianfei J Steffen Jonas Hyld JH Thulstrup Peter Waaben PW Pedersen Jannik Nedergaard JN Sauerland Max B MB Otzen Daniel E DE Hawkins Clare L CL Gourdon Pontus P Davies Michael J MJ Hägglund Per P
Scientific reports 20221221 1
Anastellin, a recombinant protein fragment from the first type III module of fibronectin, mimics a partially unfolded intermediate implicated in the assembly of fibronectin fibrils. Anastellin influences the structure of fibronectin and initiates in vitro fibrillation, yielding "superfibronectin", a polymer with enhanced cell-adhesive properties. This ability is absent in an anastellin double mutant, L37AY40A. Here we demonstrate that both wild-type and L37AY40A anastellin affect fibronectin pro ...[more]