Ontology highlight
ABSTRACT:
INSTRUMENT(S): Orbitrap Fusion Lumos
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2
SUBMITTER: Valentine Courouble
LAB HEAD: Patrick R Griffin
PROVIDER: PXD033748 | Pride | 2022-12-19
REPOSITORIES: Pride
Science advances 20221209 49
SARS-CoV-2, a human coronavirus, is the causative agent of the COVID-19 pandemic. Its genome is translated into two large polyproteins subsequently cleaved by viral papain-like protease and main protease (Mpro). Polyprotein processing is essential yet incompletely understood. We studied Mpro-mediated processing of the nsp7-11 polyprotein, whose mature products include cofactors of the viral replicase, and identified the order of cleavages. Integrative modeling based on mass spectrometry (includi ...[more]