Proteomics

Dataset Information

0

Hydrophobic-hydration hydrophilic interaction (H3I) capturing intact glycopeptides


ABSTRACT: H3I was adopted to idetify the glycosylation of bovine fetuin, human ACE2 and SARS-CoV-2 S1 proteins. Both N- and O-linked glycopeptides are successfully captured with significant enrichment rate improvements, especially for O-glycopeptides with relatively lower hydrophilicity. The majority of N- and O-glycosylation within SARS-CoV-2 S1 and hACE2 proteins are characterized simultaneously by H3I strategy, including 10 novel O-glycosylation regions with important functions in viral fusion and antibody evasion.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Jing Liu  

LAB HEAD: Jing Liu

PROVIDER: PXD033779 | Pride | 2023-04-06

REPOSITORIES: Pride

Similar Datasets

2022-11-02 | PXD037229 | Pride
2019-11-25 | PXD015335 | Pride
2022-02-16 | PXD029218 | Pride
2019-08-26 | PXD014713 | Pride
2021-11-03 | PXD022896 | Pride
2022-03-04 | PXD031025 | Pride
2022-02-17 | PXD025967 | Pride
2018-12-05 | PXD009476 | Pride
2023-02-08 | PXD030670 | Pride
2022-02-17 | PXD025886 | Pride