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Mechanism of protein corona and surface modification of MSNs affecting the tissue distribution

ABSTRACT: Once NPs were administered into the physiological condition, several serum proteins could adsorb rapidly onto the NPs to form a protein layer (also called protein corona). The effect of protein corona surrounding the NPs depends on several parameters such as size, charge and other surface properties of NPs, which could contribute a great deal of influence in determining the NP's fate.

INSTRUMENT(S): Orbitrap Fusion Lumos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Blood Serum

SUBMITTER: Chih-Ming Chou

LAB HEAD: Chih-Ming Chou

PROVIDER: PXD033783 | Pride | 2022-08-12

REPOSITORIES: Pride

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Bridging Size and Charge Effects of Mesoporous Silica Nanoparticles for Crossing the Blood-Brain Barrier.

Chen Yi-Ping YP Chou Chih-Ming CM Chang Tsu-Yuan TY Ting Hao H Dembélé Julien J Chu You-Tai YT Liu Tsang-Pai TP Changou Chun A CA Liu Chien-Wei CW Chen Chien-Tsu CT

Frontiers in chemistry 20220627

The blood-brain barrier (BBB) is a highly selective cellular barrier that tightly controls the microenvironment of the central nervous system to restrict the passage of substances, which is a primary challenge in delivering therapeutic drugs to treat brain diseases. This study aimed to develop simple surface modifications of mesoporous silica nanoparticles (MSNs) without external stimuli or receptor protein conjugation, which exhibited a critical surface charge and size allowing them to cross th ...[more]

PMID: 35880111

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