Quantitative proteomics of nutrient starved wildtype (WT) and MTM1 knock out (KO) HeLa cells.
Ontology highlight
ABSTRACT:
INSTRUMENT(S): LTQ Orbitrap Elite
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Hela Cell
SUBMITTER: 
Wonyul Jang
LAB HEAD: Volker Haucke
PROVIDER: PXD033850 | Pride | 2022-12-22
REPOSITORIES: Pride
Publications
Endosomal lipid signaling reshapes the endoplasmic reticulum to control mitochondrial function.
Jang Wonyul W Puchkov Dmytro D Samsó Paula P Liang YongTian Y Nadler-Holly Michal M Sigrist Stephan J SJ Kintscher Ulrich U Liu Fan F Mamchaoui Kamel K Mouly Vincent V Haucke Volker V
Science (New York, N.Y.) 20221216 6625
Cells respond to fluctuating nutrient supply by adaptive changes in organelle dynamics and in metabolism. How such changes are orchestrated on a cell-wide scale is unknown. We show that endosomal signaling lipid turnover by MTM1, a phosphatidylinositol 3-phosphate [PI(3)P] 3-phosphatase mutated in X-linked centronuclear myopathy in humans, controls mitochondrial morphology and function by reshaping the endoplasmic reticulum (ER). Starvation-induced endosomal recruitment of MTM1 impairs PI(3)P-de ...[more]
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