Proteomics

Dataset Information

Proteomic profiling of KIT-containing EVs secreted by neoplastic human mast cells (SUB2)

ABSTRACT: Activating mutations in the receptor KIT promote the dysregulated proliferation of human mast cells (huMCs). The resulting neoplastic huMCs secrete extracellular vesicles (EVs) that can transfer oncogenic KIT among other cargo into recipient cells. Despite potential contributions to diseases, KIT-containing EVs have not been thoroughly investigated. Here, we isolated KIT-EV subpopulations released by neoplastic huMCs using an immunocapture approach that selectively isolates EVs containing KIT in its proper topology. Proteomic profiling was performed on KIT-containing EVs compared to KIT-depleted EV populations, and on KIT-EVs that are microvesicle- and exosome-like.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Blood Cell, Blood

DISEASE(S): Disease Free

SUBMITTER: David Anderson  

LAB HEAD: Dean Darrel Metcalfe

PROVIDER: PXD033890 | Pride | 2025-12-02

REPOSITORIES: Pride

Json Xml

Dataset's files

Source:
Action DRS
Arg6_Lys6__1.allSpectra.CID.ITMS.iso_0.apl Other
Arg6_Lys6__1.allSpectra.CID.ITMS.iso_1.apl Other
Arg6_Lys6__1.allSpectra.CID.ITMS.iso_10.apl Other
Arg6_Lys6__1.allSpectra.CID.ITMS.iso_11.apl Other
Arg6_Lys6__1.allSpectra.CID.ITMS.iso_12.apl Other
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