Proteomics

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Protein interaction partners of long non-coding RNA NUDT6 in human aortic smooth muscle cells

ABSTRACT: The long non-coding RNA NUDT6 was found to be deregulated in abdominal aortic aneurysm (AAA) with higher expression in diseased human tissue specimens versus control aortic tissue. Apart from the already well-studied DNA: RNA interaction as a natural antisense transcript to Fibroblast Growth Factor 2 (FGF2), we were interested in identifying protein interaction partners to unravel further involvement in the pathogenesis and progression of abdominal aortic aneurysm. Therefore, we performed a RNA pulldown experiment using biotinylated NUDT6 and control RNA in human aortic smooth muscle cell lysate to identify further interaction partners.

INSTRUMENT(S): Q Exactive

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Ilka Wittig  

LAB HEAD: Lars Mägdefessel

PROVIDER: PXD033922 | Pride | 2024-01-26

REPOSITORIES: Pride

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Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression.

Winter Hanna H   Winski Greg G   Busch Albert A   Chernogubova Ekaterina E   Fasolo Francesca F   Wu Zhiyuan Z   Bäcklund Alexandra A   Khomtchouk Bohdan B BB   Van Booven Derek J DJ   Sachs Nadja N   Eckstein Hans-Henning HH   Wittig Ilka I   Boon Reinier A RA   Jin Hong H   Maegdefessel Lars L  

Molecular therapy : the journal of the American Society of Gene Therapy 20230505 6

Long non-coding RNAs (lncRNAs) orchestrate various biological processes and regulate the development of cardiovascular diseases. Their potential therapeutic benefit to tackle disease progression has recently been extensively explored. Our study investigates the role of lncRNA Nudix Hydrolase 6 (NUDT6) and its antisense target fibroblast growth factor 2 (FGF2) in two vascular pathologies: abdominal aortic aneurysms (AAA) and carotid artery disease. Using tissue samples from both diseases, we dete  ...[more]

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