Proteomics

Dataset Information

0

Proteome analysis of HEK293 cells stably expressing wild-type and mutated AGAL enzyme


ABSTRACT: Fabry disease is an X-linked condition caused by variants of the GLA gene that result in the absence or enzymatic deficiency of alpha-galactosidase A (AGAL). This enzyme defect leads to lysosomal storage of globotriaosylceramide (Gb3Cer) in a variety of cell types throughout the body and manifests as a multisystemic disease. We investigated changes in the proteome of HEK293 cells stably expressing WT and mutated alpha-galactosidase A enzyme (p.L394P and p.R112H) with a C-terminal FLAG tag.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cell Culture

SUBMITTER: Pavel Talacko  

LAB HEAD: Stanislav Kmoch

PROVIDER: PXD033936 | Pride | 2025-11-06

REPOSITORIES: Pride

Dataset's files

Source:
Action DRS
20200127_human_rew_uni.fasta Fasta
739-1.raw Raw
739-2.raw Raw
739-3.raw Raw
739-4.raw Raw
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