Proteomics

Dataset Information

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Quinone reductase 2-dependent HCT116 proteome

ABSTRACT: NQO2/QR2 is related to NQO1, a known quionine reductase that functions in detoxicification for cells. NQO2, however, uses a distinct co-substate with uncertain availability in cells and as a result the functions of NQO2 are poorly understood. Here, to gain insight into potential pathways regulated by NQO2, we performed label-free proteomics on isogenic control and NQO2 knockout HCT116 colon cancer cells.

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Permanent Cell Line Cell

SUBMITTER: Matthew Maitland  

LAB HEAD: Brian Shilton

PROVIDER: PXD033944 | Pride | 2023-08-15

REPOSITORIES: Pride

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Publications

Specific quinone reductase 2 inhibitors reduce metabolic burden and reverse Alzheimer's disease phenotype in mice.

Gould Nathaniel L NL   Scherer Gila R GR   Carvalho Silvia S   Shurrush Khriesto K   Kayyal Haneen H   Edry Efrat E   Elkobi Alina A   David Orit O   Foqara Maria M   Thakar Darshit D   Pavesi Tommaso T   Sharma Vijendra V   Walker Matthew M   Maitland Matthew M   Dym Orly O   Albeck Shira S   Peleg Yoav Y   Germain Nicolas N   Babaev Ilana I   Sharir Haleli H   Lalzar Maya M   Shklyar Boris B   Hazut Neta N   Khamaisy Mohammad M   Lévesque Maxime M   Lajoie Gilles G   Avoli Massimo M   Amitai Gabriel G   Lefker Bruce B   Subramanyam Chakrapani C   Shilton Brian B   Barr Haim H   Rosenblum Kobi K  

The Journal of clinical investigation 20231002 19

Biological aging can be described as accumulative, prolonged metabolic stress and is the major risk factor for cognitive decline and Alzheimer's disease (AD). Recently, we identified and described a quinone reductase 2 (QR2) pathway in the brain, in which QR2 acts as a removable memory constraint and metabolic buffer within neurons. QR2 becomes overexpressed with age, and it is possibly a novel contributing factor to age-related metabolic stress and cognitive deficit. We found that, in human cel  ...[more]

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