Posttranslational splicing modifications as a key mechanism in cytarabine resistance in AML

ABSTRACT: Despite the approval of several drugs for AML, cytarabine is still widely used as a therapeutic approach. However, most patients show resistance and only 10% of them overcome the disease. Using high-throughput screening analysis, we show that phosphorylation levels of SR proteins were elevated during cytarabine resistance. Moreover, phosphorylation of SR proteins at diagnosis was different between responder and non-responder patients, pointing to their utility to predict response. These changes correlated with altered transcriptomic profiles of SR protein target genes.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

SUBMITTER: Eduardo Zarzuela  

LAB HEAD: Javier Muñoz Peralta

PROVIDER: PXD034010 | Pride | 2023-07-04

REPOSITORIES: Pride