The role of RelA in RSV-mediated N-glycosylation
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Epithelial Cell
DISEASE(S): Viral Pneumonia
SUBMITTER: 
Yingxin Zhao
LAB HEAD: Yingxin Zhao
PROVIDER: PXD034013 | Pride | 2022-08-11
REPOSITORIES: Pride
Publications
RELA∙8-Oxoguanine DNA Glycosylase1 Is an Epigenetic Regulatory Complex Coordinating the Hexosamine Biosynthetic Pathway in RSV Infection.
Xu Xiaofang X Qiao Dianhua D Pan Lang L Boldogh Istvan I Zhao Yingxin Y Brasier Allan R AR
Cells 20220715 14
Respiratory syncytial virus (RSV), or human orthopneumovirus, is a negative-sense RNA virus that is the causative agent of severe lower respiratory tract infections in children and is associated with exacerbations of adult lung disease. The mechanisms how severe and/or repetitive virus infections cause declines in pulmonary capacity are not fully understood. We have recently discovered that viral replication triggers epithelial plasticity and metabolic reprogramming involving the hexosamine bios ...[more]
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