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The HLA peptide repertoire of SaOS-2 cell line transfected with TP53 protein

ABSTRACT: Analysis of the immunopeptidome of Human Leukocyte Antigen(HLA)class I of SaOS-2 osteosarcoma cells transfected with pBR322 vector only, and 2 mutants of TP53 protein namely R175H and R273H.

INSTRUMENT(S): TripleTOF 5600

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Epithelial Cell, Cell Culture

DISEASE(S): Disease Free

SUBMITTER: Kirti Pandey

LAB HEAD: Anthony Wayne Purcell

PROVIDER: PXD034044 | Pride | 2022-10-13

REPOSITORIES: Pride

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Multi-Omic Analysis of Two Common P53 Mutations: Proteins Regulated by Mutated P53 as Potential Targets for Immunotherapy.

Vadakekolathu Jayakumar J Boocock David J DJ Pandey Kirti K Guinn Barbara-Ann BA Legrand Antoine A Miles Amanda K AK Coveney Clare C Ayala Rochelle R Purcell Anthony W AW McArdle Stephanie E SE

Cancers 20220817 16

The p53 protein is mutated in more than 50% of human cancers. Mutated p53 proteins not only lose their normal function but often acquire novel oncogenic functions, a phenomenon termed mutant p53 gain-of-function. Mutant p53 has been shown to affect the transcription of a range of genes, as well as protein-protein interactions with transcription factors and other effectors; however, no one has intensively investigated and identified these proteins, or their MHC presented epitopes, from the viewpo ...[more]

PMID: 36010968

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