Chronic hypoxic response in rod photoreceptors
Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Mus Musculus (mouse)
TISSUE(S): Brain
SUBMITTER: 
Vyara Todorova
LAB HEAD: Christian Grimm
PROVIDER: PXD034057 | Pride | 2025-04-29
REPOSITORIES: Pride
Dataset's files
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Publications
Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation.
Todorova Vyara V Stauffacher Mia Fee MF Ravotto Luca L Nötzli Sarah S Karademir Duygu D Ebner Lynn J A LJA Imsand Cornelia C Merolla Luca L Hauck Stefanie M SM Samardzija Marijana M Saab Aiman S AS Barros L Felipe LF Weber Bruno B Grimm Christian C
Molecular neurodegeneration 20230307 1
<h4>Background</h4>Major retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and retinal detachment, are associated with a local decrease in oxygen availability causing the formation of hypoxic areas affecting the photoreceptor (PR) cells. Here, we addressed the underlying pathological mechanisms of PR degeneration by focusing on energy metabolism during chronic activation of hypoxia-inducible factors (HIFs) in rod PR.<h4>Methods</h4>We used two-photon ...[more]
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