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Mus_Oocyte_LC-MS/MS-mRBPome capture of oocytes identifies the RNA-binding protein LSM14B,an essential regulator of meiosis in mouse oocytes

ABSTRACT: A quantitative mass-spectrometry-based proteome profiles of oocytes in WT and Lsm14b KO mouse

INSTRUMENT(S): LTQ Orbitrap Velos

ORGANISM(S): Mus Musculus (mouse)

TISSUE(S): Cell Culture, Oocyte

SUBMITTER: Li Hui

LAB HEAD: Su you-qiang

PROVIDER: PXD034070 | Pride | 2023-07-20

REPOSITORIES: Pride

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LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice.

Li Hui H Zhao Hailian H Yang Chunhui C Su Ruibao R Long Min M Liu Jinliang J Shi Lanying L Xue Yuanchao Y Su You-Qiang YQ

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20230421 18

Mammalian oogenesis features reliance on the mRNAs produced and stored during early growth phase. These are essential for producing an oocyte competent to undergo meiotic maturation and embryogenesis later when oocytes are transcriptionally silent. The fate of maternal mRNAs hence ensures the success of oogenesis and the quality of the resulting eggs. Nevertheless, how the fate of maternal mRNAs is determined remains largely elusive. RNA-binding proteins (RBPs) are crucial regulators of oogenesi ...[more]

PMID: 37083226

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