Ontology highlight
ABSTRACT:
INSTRUMENT(S): Q Exactive HF
ORGANISM(S): Homo Sapiens (human)
TISSUE(S): Cell Culture
DISEASE(S): Parkinson's Disease
SUBMITTER: Katharina Zittlau
LAB HEAD: Boris Macek
PROVIDER: PXD034136 | Pride | 2025-05-26
REPOSITORIES: Pride
Items per page: 5 1 - 5 of 85 |
Lechado-Terradas Anna A Schepers Sandra S Zittlau Katharina I KI Sharma Karan K Ok Orkun O Fitzgerald Julia C JC Geimer Stefan S Westermann Benedikt B Macek Boris B Kahle Philipp J PJ
Autophagy reports 20221219 1
PINK1/parkin-dependent mitophagy initially involves (phospho)ubiquitin-directed proteasome-dependent degradation of certain outer mitochondrial membrane (OMM) proteins (e.g. mitofusins) and the recruitment of autophagy adaptors to a group of ubiquitinated OMM proteins, eventually leading to autophagic removal of damaged mitochondria in stressed cells. Here we provide evidence that mitochondrial degradation occurs via stepwise delivery of separate mitochondrial sub-compartments for autophagic deg ...[more]