Proteomics

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Role of RNA binding protein PgRBP1 in alteration of protein profile of Porphyromonas gingivalis


ABSTRACT: The oral periodontal pathogen Porphyromonas gingivalis must adapt to ever changing environment to survive and cause disease. So far most of the efforts concerning the regulatory mechanisms employed by the bacterium centered on DNA-binding regulators. Here we focused on a RNA-binding protein that is indispensable for the bacterium to survive with host cells. We have determined the proteome affected by deletion of the protein, designated here PgRBP1. Three strains were used: WT, PgRBP1-deficient strain designated V3139 and a complemented strain V3236. In total, 1,393 proteins were identified. 592 proteins in the comparison of P. gingivalis 3139 vs. WT, 228 proteins in the comparison of P. gingivalis 3236 vs. WT, and 276 proteins in the comparison of P. gingivalis 3139 vs. 3236 showed differential level with statistical significance

INSTRUMENT(S): LTQ Orbitrap Elite

ORGANISM(S): Porphyromonas Gingivalis (strain Atcc Baa-308 / W83)

SUBMITTER: Janina Lewis  

LAB HEAD: Janina P Lewis

PROVIDER: PXD034144 | Pride | 2025-06-02

REPOSITORIES: Pride

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The <i>Porphyromonas gingivalis</i> RNA-binding protein is required for growth in high levels of zinc and persistence with host cells.

Yanamandra Sai S   Marsh Holly H   Cvitkovic Romana R   Gui Qin Q   Belvin Benjamin R BR   Lewis Janina P JP  

Frontiers in cellular and infection microbiology 20250515


The oral periodontal pathogen <i>Porphyromonas gingivalis</i> must adapt to an ever-changing environment to survive and cause disease. So far, most of the efforts concerning the regulatory mechanisms employed by the bacterium centered on DNA-binding regulators. Although global regulatory mechanisms employing RNA-binding proteins (RBP) are reported in most forms of life so far, such mechanism of regulation remains unknown in the oral Bacteroidetes group. Examination of the genome of <i>P. gingiva  ...[more]

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