Src Family Kinases as potential therapeutic targets for chemotherapy-resistant triple negative breast cancer

ABSTRACT: Here we quantified tyrosine phosphorylation (pTyr) mediated signaling networks in chemotherapy sensitive (CS) and resistant (CR) TNBC patient derived xenografts (PDX) to gain novel therapeutic insights. We identified Src Family Kinases (SFKs) as potential therapeutic targets in CR TNBC PDXs. Additionally, we performed pTyr analysis on tumor specimens derived from TNBC patients and observed lower prevalence of SFK driven tumors.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Primary Cell

DISEASE(S): Breast Cancer

SUBMITTER: Ishwar Kohale  

LAB HEAD: Forest M. White

PROVIDER: PXD034154 | Pride | 2022-10-13

REPOSITORIES: Pride