Protein Profiling of human iPSC-derived cardiomyocytes with mutations in ACTN2

ABSTRACT: Genetic variants in α-actinin 2 (ACTN2) are associated with several forms of (cardio)myopathy. Here, we analyzed the proteome of 2D and EHT cultured cardiomyocytes derived from mutant-expressing (ACTN2mut) and a wild-type-expressing (ACTN2wt) hiPSC lines, both created with CRISPR/Cas9 genetic tools.

INSTRUMENT(S):

ORGANISM(S): Homo Sapiens (human)

TISSUE(S): Cardiocyte

DISEASE(S): Cardiovascular System Disease

SUBMITTER: Elke Hammer  

LAB HEAD: Dr. Elke Hammer

PROVIDER: PXD034258 | Pride | 2022-10-13

REPOSITORIES: Pride